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Combatting Cancer
Biology professor Nancy Krucher, PhD, understands the transformative power of research. She男女操逼视频软件檚 a pioneer in the fight against breast cancer, and she男女操逼视频软件檚 just received a three-year $400,241 grant from the National Cancer Institute (NCI) through the National Institutes of Health (NIH) to study new methods to combat cancer cell development of resistance to targeted treatments.
男女操逼视频软件淐ancer is a major health concern in our country and throughout the world,男女操逼视频软件 said Professor Krucher. 男女操逼视频软件淐urrently, much of cancer research focuses on identifying specific mutations or abnormalities in tumor cells and creating drugs that target them. These targeted therapies have exhibited a great deal of success in some cancer types. Unfortunately, while targeted therapies usually work for a few months or a few years, cancer cells often develop resistance to these agents.男女操逼视频软件
Targeted therapies颅男女操逼视频软件攚hich involve certain drugs used to specifically target the ways in which cancer cells grow, divide, and spread男女操逼视频软件攁re becoming more common in cancer treatment. However, cancer cells can acquire resistance to the targeted agent, making the treatment less effective. ATP-citrate lyase (ACLY) is a critical enzyme in cancer cell growth that can be activated as a response to targeted therapies, particularly in treatment of breast cancer and melanoma, often resulting in poor prognosis.
In February 2020, the FDA approved a new ACLY inhibitor, and another was recently developed. In this project, these agents are predicted to have anti-cancer activity. Krucher男女操逼视频软件檚 research aims to investigate the hypothesis that targeting ACLY with these inhibitors can reverse resistance in breast cancer and melanoma.
男女操逼视频软件淭hrough this grant, Professor Krucher and our biology students have the opportunity to uncover critical information that could improve the effectiveness of these vital treatments.男女操逼视频软件
Because the newly developed ACLY inhibitors that will be used in this study have largely not been tested on cancer cells to date, Krucher hopes her work can provide new insight for cancer treatment, including the development of novel drug combination regimens. Additionally, Krucher男女操逼视频软件檚 work will employ an in vivo model of cancer metastasis in melanoma as well as three-dimensional cancer cell cultures, an innovative and effective approach to studying the physiological tumor environment.
Undergraduate biology students will also be closely involved in this research, carrying out a majority of the experiments outlined in the study, helping prepare them for careers in the biomedical research workforce.
男女操逼视频软件淧rofessor Krucher is doing incredibly important work in the field of cancer research, an area of biomedicine that touches so many lives around the world,男女操逼视频软件 said Tresmaine R. Grimes, PhD, dean of the Dyson College of Arts and Sciences and School of Education. 男女操逼视频软件淭hrough this grant, Professor Krucher and our biology students have the opportunity to uncover critical information that could improve the effectiveness of these vital treatments.男女操逼视频软件
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